peter attia paul grewal covid-19

AMA with Dom D’Agostino, Ph.D., Part II of II: Ketosis for Cancer and Chronic Disease, Hyperbaric Oxygen Therapy, And The Effect Of Ketosis On Female Health | The Drive with Peter Attia #120

Key Takeaways

  • Ketone metabolic therapy (AKA Therapeutic Ketosis) disrupt tumor growth and proliferation which weakens the tumor
  • Ketone bodies are not a good source of fuel for cancer cells
  • A lower glucose-ketone index (ideally, 1 or 2) sets the stage to slow tumor growth and proliferation
  • “If you reduce glucose availability, inhibit insulin – you’re creating a scenario where if you give an oxidative challenge with hyperbaric oxygen therapy, you can potentially kill cancer” – Dr. Dom D’Agostino
  • Two potential combination treatments for cancer: 1) Hyperbaric oxygen therapy + radiation + IV vitamin C – or – 2) hyperbaric oxygen + IV vitamin C

Introduction

Bob Kaplan, Head of Research at Attia Medical, PC continues his conversation with Dr. Dom D’Agostino for Part II of II of a special Ask Me Anything about all things ketogenic diet and cancer. Note, this is only a preview. The full episode is only available to subscribers.

Dr. Dom D’Agostino (@DominicDAgosti2) is an academic researcher and expert on ketones and the ketogenic diet

Hosts: Peter Attia (@PeterAttiaMD) and Bob Kaplan Bob Kaplan (@bobkaplan)

Ketosis and Cancer Background

  • Ketone metabolic therapy (AKA Therapeutic Ketosis) disrupt tumor growth and proliferation which weakens the tumor
  • Ketone bodies are not a good source of fuel for cancer cells
  • Being in a state of ketosis suppresses insulin signaling which drives PI3-kinase, lowers glucose availability to the tumor, and elevates ketone bodies
  • Tumors are resilient because they have upregulated antioxidant pathways by high levels of glutathione
  • A new publication outlines a case of metastatic thymoma which was treated with a combination of a ketogenic diet, water fasting, and prednisone and led to apoptosis in cancer cells and a 96% decrease in tumor burden  

Press-Pulse Therapy

  • “Press-pulse” describes the shift from respiration to fermentation of cancer cells as glucose and glutamine become prime fuels for tumor growth
  • From a press-pulse perspective, we need to control glucose-ketone index

Hyperbaric Oxygen, IV Vitamin C, and Cancer

Hyperbaric oxygen

  • “If you reduce glucose availability, inhibit insulin – you’re creating a scenario where if you give an oxidative challenge with hyperbaric oxygen therapy, you can potentially kill cancer” – Dr. Dom D’Agostino
  • New research is extrapolating from the fact that radiation therapy kills cancer cells by 80-90% by generating reactive oxygen species which are toxic to tumor cells  
  • Hyperbaric oxygen therapy before or after radiation therapy, could increase residual reactive oxygen species and dramatically sensitize tumor cells
  • Modified ketogenic diet with hyperbaric oxygen delivered for 60 minutes 3x/week, decreased tumor burden and extended lifespan in an animal model of metastatic cancer

Intravenous (IV) vitamin C

  • At high doses, vitamin C is a pro-oxidant
  • If you elevate vitamin C in the blood, it functions as a glucose antagonist so you inhibit glucose transport and increase reactive oxidant species
  • Two potential combination treatments for cancer: 1) Hyperbaric oxygen therapy + radiation + IV vitamin C – or – 2) hyperbaric oxygen + IV vitamin C
  • For more information check out Valter D. Longo’s newest article, “Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers”
Drive with Dr. Peter Attia : , , , , , , ,
Notes By Maryann

More Notes on these topics

Top Insights and Tactics From

31 Best Podcasts of All Time

FREE when you join over 12,000 subscribers to the
Podcast Notes newsletter

No Thanks