peter attia paul grewal covid-19

AMA #26: Continuous Glucose Monitors, Zone 2 Training, And A Framework For Interventions| The Drive with Peter Attia #173

Key Takeaways

  • When considering interventions, ask: what is the risk of harm? If you do X what is the probability of benefit? What is the opportunity cost?
  • The benefit of Continuous Glucose Monitoring (CGM) for people without diabetes is really is the insight it provides and the behavior change it can spark
  • The value of the first 90 days with CGM is mostly insight and raising awareness without changing behavior – then it flips


In this special episode of The Drive, Peter Attia sits down with Head of Research at Attia Medical, PC Bob Kaplan (@bobkaplan) to discuss continuous glucose monitors, getting the most from zone 2 training, and foundational framework when considering interventions. Note, this is only a preview. The full episode is only available to subscribers.

Host: Peter Attia (@PeterAttiaMD)

Framework For Interventions

  • Ask: what is the risk of harm? If you do X what is the probability of benefit? What is the opportunity cost?
  • Phase 1 studies assess harm and rarely anything else because the sample size is small
  • Phase 2 studies assess the efficacy
  • Phase 3 trials double down on efficacy and opportunity cost
  • The easiest interventions to do are pharmaceutical

Continuous Glucose Monitoring (CGM)

  • We don’t have enough Randomized Controlled Trial (RCT) data to say CGM use is beneficial in people who are not diabetic
  • Cons of CGM use: low risk of harm but can induce anxiety in some (e.g., people with eating disorders)
  • Pros of CGM use: teaches you about carbohydrate tolerance, provides an opportunity for real-time changes
  • Opportunity cost: they are expensive if you are not diabetic
  • You can gain a lot of insight using them intermittently 

First 90 days with CGM: 90% insight without behavior change, 10% behavior change – then it flips

Drive with Dr. Peter Attia : , , ,
Notes By Maryann

More Notes on these topics

Top Insights and Tactics From

31 Best Podcasts of All Time

FREE when you join over 35,000 subscribers to the
Podcast Notes newsletter

No Thanks