Stress

In this episode, James answers listener voicemails in celebration of the podcast reaching 40,000 downloads. He also shares a personal letter he wrote to himself in December of 2016.

Dr. Elissa Epel is a Professor in the Department of Psychiatry at the University of California, San Francisco. She is the co-author of "The Telomere Effect."

Dr. Robert Sapolsky is a professor of biological sciences at Stanford. He's the author of "Why Zebras Don't Get Ulcers" as well as his latest work - "Behave: The Biology of Humans at Our Best and Worst."

Keith Rabois is a General Partner at Founders Fund.

Kunal is a self-described "normal brown guy from India." He has a KILLER Twitter feed - @CrazyPolymath.

Ryan Holiday (@RyanHoliday) is a strategist and writer. He dropped out of college at 19 to apprentice under Robert Greene, author of The 48 Laws of Power, and later served as the director of marketing for American Apparel. His company, Brass Check, has advised clients like Google, TASER, and Complex, as well as many prominent

Dr. Rhonda Patrick returns with another nutrient dense discussion with Joe on cryotherapy/cold showers, diet, and exercise. As always this is not to be missed and we've noted all the most important parts for you, as it can be overwhelming in detail.

LONGEVITY, EPIGENETICS, MICROBIOME HEALTH & THE DIFFERENCE BETWEEN EATING FOR LONG-TERM WELLNESS VERSUS PERFORMANCE This episode is a geeky deep dive into the hardcore science behind everything from telomeres and the mechanisms behind aging and longevity to the primacy of maintaining microbiome health; oxidative stress and the relationship between inflammation and chronic disease; epigenetics and genetic

Rhonda speaks with Dr. Pierre Capel, professor of experimental immunology who has studied Wim Hof to bring the science to explain his incredible ability to withstand cold and summon his immune system at well. Through this insightful discussion they also cover how the immune system is impacted by stress/meditation and just how dynamic our DNA

Rhonda discusses some of the mechanisms by which chronic stress (and rumination) affect the brain and brain aging, the gut and inflammation, the immune system, and biological aging through acceleration of telomere shortening. She talks about how meditation can buffer these negative effects of stress and improve cognitive performance, brain aging and b iological aging