Episode 8: Biotracking, Age Reversal & Other Advanced Health Technologies | Lifespan With Dr. David Sinclair

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Key Takeaways

  • Our medical model of “wait until you get sick then go to the doctor” really won’t get you where you want to go – the insurance system in the U.S. won’t cover testing unless you’re sick
  • You can’t impact what you don’t measure! Be proactive about measuring and keeping track of what’s happening in your body through bloodwork and helpful wearables
  • Technology isn’t waiting for the laws: it’s a matter of when not if – we need data security and privacy protection laws in place, including the right to delete your data, before the use of wearables is rampant
  • Wearables and sensors will eventually collect thousands of data points per second and ultimately contribute to “lengthening our lives another decade beyond what we’re able to do with changes to lifestyle” – according to Dr. David Sinclair
  • The key is really to take action based on the information you’re getting from the wearables and sensors  
  • Supplementation is particularly important for people on a specialized diet – you need to be vigilant about measuring bloodwork to make sure you’re doing what’s best for your body
  • David Sinclair’s 5 biomarkers worth measuring: (1) glucose; (2) heart function (3) inflammation as measured by, c-reactive protein (CRP), tumor necrosis factor (TNF) alpha, cortisol; (4) lactate; (5) blood oxygen
  • “This is the kind of life I want for everybody, that we don’t have to worry about getting cancer in our 50s and 60s and having a heart attack in our 70s. We should be able to live to our 70s, 80s, 90s and beyond in a healthy way, contributing to society, contributing to the community, educating our kids…” – Dr. David Sinclair
  • Take responsibility for yourself, and do it for your kids and grandkids’ sake: eat the right way, fast, get exercise, give your body a little stress, supplement as needed, monitor your health proactively

Introduction

Dr. David Sinclair is a biologist, professor of genetics at Harvard, author, and expert on aging and longevity. His research and biotech companies focus on understanding why we age and how to slow its effects.

In the final episode of Lifespan season 1, David Sinclair & Matthew LaPlante focus on current on upcoming technologies relevant to health and aging. They break down the use of wearables, biological age measurements, and highlight research aimed at reversing the biological clock.

Host: David Sinclair (@davidsinclair)  Co-Host: Matthew LaPlante (@mdlaplante)

Early Cancer Detection Technology

  • The traditional medical model often waits until you have signs or symptoms of cancer before taking action
  • We don’t have to wait for tumors to grow and metastasize: when a cancer cell or tumor starts to form, it begins releasing signals in the bloodstream which can be detected at the earliest signals
  • Check out Grail – you can detect 50+ cancers before they become tumors
  • Breast cancer and lung cancer screenings and detection have made some improvements over the years but we’re still behind the ball on proactivity
  • Circulating DNA testing: liquid biopsies via blood draw can tell us what’s going on inside a patient’s body by examining circulating DNA(DNA that comes from cancerous cells and tumors)
  • Liquid biopsy technology has the power to dramatically reduce the incidence and death rate of cancer

InsideTracker

  • You can’t improve what you don’t measure InsideTracker: David Sinclair co-founded a company that can tell you biologic age and creates personalized and actionable plans to help people optimize their bodies through nutrition, supplements, and lifestyle
  • The goal is to create an actionable dashboard for the body
  • InsideTracker leverages hundreds of thousands of human data points and thousands of scientific articles to create a formula of what works and what doesn’t for your body
  • Recommendation of food and nutrition was better than leading drug at treating type 2 diabetes
  • Soon, the current model of medicine is going to outdated as machines and data will know us better than our doctor
  • “We wouldn’t drive a car without a dashboard so why would doctors do the same?” – David Sinclair

Current Noteworthy Wearables & Sensors

  • LIVMOR Halo AF Detection System: wearable FDA approved heart monitor, which provides continuous monitoring of pulse rhythms for detecting atrial fibrillation
  • ScanWatch: FDA approved smartwatch that monitors ECG and blood oxygen levels, particularly helpful for continuous monitoring – or – to send patients home from the hospital early but ensure monitoring
  • Continuous glucose monitor: worn in the arm and useful for learning what spikes blood sugar and how various foods impact blood sugar
  • Continuous glucose monitors currently require a prescription but are worth talking to your physician
  • David Sinclair’s 5 biomarkers worth measuring: (1) glucose; (2) heart function (3) inflammation as measured by, c-reactive protein (CRP), tumor necrosis factor (TNF) alpha, cortisol; (4) lactate; (5) blood oxygen
  • Not a wearable, but Viome is noteworthy home test which provides valuable information about the gut function and follows up with suggested supplementation based on results
  • Mouthguard biosensors are becoming available for concussion, lactation

The Future Of Aging & Wearables

  • Tiny implantable nano-bio sensors are being developed and will soon be released which will be implanted in the skin and can measure DNA methylation and much more
  • “I think everybody should have a biosensor in their body at every age so that parents and doctors can monitor how people are doing and make better decisions about food and lifestyle” – Dr. David Sinclair
  • The technology is improving and over time will be faster, more efficient, and less expensive
  • Tally Health by Dr. David Sinclair, coming soon with the goal of reversing biological age – get on the waitlist
  • Eventually, we’ll probably have the ability to run our own labs at home and get treatment on the spot with pills produced at home and in accordance with their genome
  • Exercise: we’ll likely have an AI personal trainer of sorts which tells you what exercise you need that day, not just that you should take a rest day because HRV is low like we can do now
  • On the horizon: epigenetic reprogramming and reset of biological age
  • Vision is being restored in blind mice which will hopefully be translated into humans soon

Data & Security

  • We’re going to hit a point where the volume of information from wearables is going to be overwhelming and we’ll need AI to help us make sense of everything – this raises a lot of data security issues
  • Questions will come up such as: who owns the data? Who is storing the data? Where is the data being stored? How will the information be HIPAA compliant? How will genetics play into this (i.e., my parents’ tests include information about me since we’re related)? What would happen with the detection of infectious diseases?
  • We need to lay the foundations and rules before we run rampant with the technology – including the right to delete your data should you choose
  • Technology isn’t waiting for the laws: it’s a matter of when, not if

Population Concerns

  • There can be side effects to gene therapy so we still have a long way to go to understand the long-term effects – we don’t know yet but there’s a lot of hope for a future of people living healthier, longer lives
  • With the possibility of longer lives, comes concerns about world overpopulation and lack of resources
  • The prediction is that humanity will peak at about 10-11 billion people and come down again
  • We need to preserve the planet and environment – a healthy population will require a smaller percentage of GDP in healthcare, freeing up trillions of dollars to use on more productive things like education, environment, etc.
  • With longer life, people can change careers and live more productively, healthily, and happily
Lifespan With Dr. David Sinclair : , , , ,
Notes By Maryann

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