10 Ways Ketones Are Protective Against Infections |High-Intensity Health with Mike Mutzel

Key Takeaways

  • Ketones and ketone bodies protect against viral infection through several modalities
  • Ketones inhibit glycolysis which can slow or stop virus growth and replication
  • Controlling inflammation is a key component to protect against infections


Mike Mutzel reviews a newly published scientific article, Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections and highlights the 10 ways ketones and ketone body metabolism may protect against infection.

Host: Mike Mutzel (@MikeMutzel)

Ketones’ Effect on Viruses and Infections

  • Metabolism and the immune system are two sides of the same coin
  • In metabolic diseases, anti-inflammatory, immune drugs are used as a treatment
  • Viruses rely on glycolysis to foster growth
  • Ketones inhibit glycolysis which is one of the main effects

Ten Ways Ketones May Offer Protection Against Viral Infection

  1. Increasing levels of NADPH enzyme complex which has been shown to help cells maintain redox status
  2. Ketone body beta-hydroxybutyrate (BHB) has been shown to increase levels of Nrf2 which activates genes involved in making anti-oxidant, anti-inflammatory, and phase 2 detoxifying enzymes
  3. A ketogenic diet can reduce pro-inflammatory signaling by inhibiting NLRP3
  4. Inhibiting HCAR2 and NF-kappa Bm, both of which are accelerators of inflammation
  5. Affect mitochondrial membrane permeability to enhance apoptosis (cell death)
  6. Inhibit glycolysis which slows or stops the growth of virus and replication
  7. Failing heart tends to rely on ketones for fuel – supporting cardiovascular output and function might be protective
  8. A hypoxic state can drive inflammation, ketones can improve tolerance to hypoxia
  9. Ketones improve blood sugar regulation
  10. Ketones possess anti-catabolic and cognitive preservation properties
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Notes By Maryann

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