The ABCs of Alzheimer’s Prevention – The Peter Attia Drive

Check out The Peter Attia Drive podcast page

This is Peter’s (@PeterAttiaMD) new short podcast series, The Qualys, available only to paying subscribers (except for periodic episodes like this one). This clip is from Peter’s interview with Richard Issacson, MD.

Key Takeaways

  • The ABC’s of Alzheimer’s Prevention
    • A: Anthropometrics – This includes body fat, lean mass, and visceral fat
    • B: Biomarkers – Specifically cholesterol markers
      • The basics –  LDL, HDL, triglycerides
      • The extensive – ApoB, particle subtype, LDL-p
      • Other biomarkers Richard focuses on – markers of inflammation (hsCRP, fibrinogen, lplA-2, myeloperoxidase)
        • “HsCRP is probably;y the most informative”
      • Peter adds – “You do more detailed lipid profiling than most cardiologists do”
    • C: Cognitive Function
      • As mentioned in these Podcast Notes, cognitive activity wards off cognitive decline
      • Exercise is the most important thing you can do to perverse brain health
      • Supplementing with EPA and DHA is thought to reduce risk of Alzheimer’s
  • Alzheimer’s Research
    • “Alzheimer’s prevention is so underfunded. It is an embarrassment to this disease state.”
    • The success rate of pharmacology for Alzheimer’s disease is 0.4%
      • 99.6% of drugs brought forth to treat Alzheimer’s disease are failures
      • For this reason, it’s much more effective to fund Alzheimer’s prevention research rather than Alzheimer’s disease treatment research
        • At this time, of every $100 allotted to Alzheimer’s disease research, $99.90 are going to Alzheimer’s disease treatment
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