Tim visited the Googleplex — the Mountain View-based headquarters of Google — and had a public chat. I was interviewed and made sure that we covered some ground that has not been discussed before. There were questions such as:
What has been the most important Stoic teaching that I’ve come across?
How do I manage the many requests I receive?
What are the factors or elements that have led to the success of the podcast?
Where do I see myself in five years?
If I could pick three people — alive or dead — to be in my personal board of directors, who would they be?
How do I experiment with my dog training?
What are my recommendations for longevity?
How do I fight insomnia?
Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health. If you enjoyed my last episode with Dr. Satchin Panda, I have good news! This will also be a great episode for you, since we talk about some similar ideas, but focus more on the human side of things, especially when it comes to time-restricted eating, since Dr. Patterson does primarily clinical research. In this 45-minute podcast, we talk about… The importance of time-restricted eating as a practical public health intervention, mostly for it’s ease of implementation, that may have a widespread impact on disease risk. Why you should probably make sure your time-restricted eating window occurs earlier in the day, rather than later. How the first 5% drop in weight loss can have disproportionately large effects on the metabolic factors associated with breast cancer risk when compared with subsequent weight loss. The association of longer fasting durations beginning earlier in the evening and improved sleep in humans, as well as spontaneous physical activity in their day-to-day lives. The relationship between metabolism and breast cancer risk. The effect of lifestyle factors, such as obesity, physical activity, what and even when you eat, whether or not you smoke tobacco… and how even modest changes, such as consuming food earlier in the day and only during an 11-hour window, can decrease breast cancer risk and recurrence by as much as 36%. The importance of starting your fast earlier in the evening, and how an earlier eating window has been shown to correlate to reductions in inflammatory markers.
Dr. Dominic “Dom” D’Agostino (@DominicDAgosti2) is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast.
Dom focuses on ketosis, ketones, and the ketogenic diet — so you can consider this a ketosis master class (especially if you combine both episodes, though this one does stand alone).
If you have an interest in these types of metabolic therapies, whether for performance enhancement, endurance, weight loss, or fighting cancer, diabetes, or any number of other maladies, you will find a gem within this episode.
Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin’s work deals specifically with the timing of food and it’s relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. In this video we discuss… The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. The relationship between our body’s “master clock” and it’s many peripheral clocks. Why infants sleep so intermittently, instead of resting for a longer, sustained duration like healthy young adults… and why this sustained rest also goes haywire in the elderly. The fascinating work Dr. Panda took part in that lead to the discovery of a specialized light receptor in the eye that sets circadian rhythms and is known as melanopsin. The important relationship between the relatively light insensitive melanopsin, which requires around 1,000 lux of light to be fully activated, and its control of the circadian clock by means of activation of the suprachiasmatic nucleus and suppression of melatonin. The effects light exposure seems to have on next-day cortisol, a glucocorticoid hormone that regulates around 10-20% of the human protein-encoding genome. The clever experimental design by which Dr. Panda and his colleagues discovered that certain circadian rhythms, especially of the liver, are entrained by when we eat, instead of how much light we get. This underlines the fact that, when managing are circadian rhythm, both elements are important! One of the more surprising effects of time-restricted feeding in mice eating a so-called healthy diet: increases in muscle mass and even endurance in some cases. Interested in trying out time-restricted feeding? Don’t let your data points go to waste! You can try out time-restricted feeding and have a real impact on human research! Commit to 14 weeks and download Dr. Panda’s mobile app to get started. Learn more at: mycircadianclock.org/participant
Seth Godin (@thisissethsblog) is the author of 17 bestselling books that have been translated into more than 35 languages. He writes about the way ideas spread, marketing, strategic quitting, leadership, and — most of all — challenging the status quo in all areas. His books include Linchpin, Tribes, The Dip, Purple Cow, and What to Do When it’s Your Turn (and it’s Always Your Turn).
Seth has founded several companies, including Yoyodyne and Squidoo. His blog (which you can find by typing “Seth” into Google) is one of the most popular in the world. In 2013, Godin was inducted into the Direct Marketing Hall of Fame. Recently, Godin turned the book publishing world on its ear by launching a series of four books via Kickstarter. The campaign reached its goal in just three hours and became the most successful book project in Kickstarter history.
Dr. Rhonda Patrick returns with another nutrient dense discussion with Joe on cryotherapy/cold showers, diet, and exercise. As always this is not to be missed and we’ve noted all the most important parts for you, as it can be overwhelming in detail.
Rhonda speaks with Dr. Pierre Capel, professor of experimental immunology who has studied Wim Hof to bring the science to explain his incredible ability to withstand cold and summon his immune system at well. Through this insightful discussion they also cover how the immune system is impacted by stress/meditation and just how dynamic our DNA really is.
Dubner speaks with Kenji Lopez-Alt of Serious Eats fame. Kenji makes Alton Brown’s approach to food look childish. This is a wonderful show chock full of great cooking tips for delicious foods (as well as ways to simply eat healthier from some of the other guests). If you’re into cooking or being healthier, you’ll enjoy this one.
New to Podcastnotes, Bulletproof Podcast. Our first set of notes digs into the microbiome, gut health, and fermentation.
Summer Bock is a Master Fermentationist who guides people to experience a deeper level of healing. Her mission is to radically improve people’s health while empowering them to revolutionize the local food system using delicious, local and healthy food. A skilled herbalist with a background in microbiology, she is certified by the Institute of Integrative Nutrition and Columbia University. Summer has created an avid following with her signature programs The Probiotic Power Cleanse, Gut Rebuilding, and the yearlong Fermentationist Certification Program. Here is a chapter out of Summer’s book, Gut Rebuilding.
Rhonda discusses some of the mechanisms by which chronic stress (and rumination) affect the brain and brain aging, the gut and inflammation, the immune system, and biological aging through acceleration of telomere shortening. She talks about how meditation can buffer these negative effects of stress and improve cognitive performance, brain aging and b iological aging in general.