Dr. Roland Griffiths is a pioneer in psychopharmacology research, having worked for over 40 years with mood-altering substances. Nearly two decades ago, Dr. Griffiths created the psilocybin research program at Johns Hopkins University.
Most recently his research demonstrated that high-dose synthetic psilocybin, when administered in a safe and clinical setting under the guidance of a team of professionals, was able to have a lasting effect on depression and anxiety in patients with life-threatening cancer mediated through mystical experiences that have a phenomenology and psychometric pattern that corresponds to the same sort of religious or mystical experiences documented throughout human history.
In addition to this most recent research, however, Dr. Griffiths has also done research on: the effects it can have on the so-called personality domain of openness, its effects in beginning and long-term meditators, and the effects it has on enhancing smoking cessation. He’s been a part of brain imaging studies and explored its pharmacological and neural mechanisms of action and conducted surveys on so-called “bad trips”, as well as looked at drug interactions.
This was a dense one, thank god for notes!
Joe Rogan sat down with ketogenic diet expert Dom D’Agastino. They discuss the benefits of running on fat for fuel, exogenous ketone supplementation, the ketogenic diet and cancer treatment, fasting, and the many other benefits of being in a state of metabolic ketosis. Enjoy!
James Altucher sat down with Shawn Stevenson of the Model Health Show and author of “Sleep Smarter: 21 Essential Ways to Sleep Your Way to a Better Body, Better Health, and Bigger Success” to discuss all things health. Shawn himself used to be severely overweight. One day he decided he needed to get things into gear and completely changed how he was living. James and Shawn get into why we need to exercise, how we should eat, where our water should come from, and of course, why we all need more sleep.
An amazing Q&A with the one and only Dom D’Agostino.
Dom is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC) — which is mentioned in the current issue of Outside Magazine (on which there’s a clown who looks a lot like me).
Much of Dom’s work is related to metabolic therapies and nutritional strategies for peak performance and resilience in extreme environments. Dom’s research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), and other private organizations and foundations.
We go down-down the rabbit hole and talk all things brain enhancement.
LISTEN The guest on this episode of the podcast is Jason Nemer, co-founder of AcroYoga. What are the origins of AcroYoga? Jason had some sport acrobat experience, a mix between gymnastics and figure skating. Jenny had experience in therapeutic flying. AcroYoga is the combination of those two practices. It helps with flexibility and mobility. What … Continue reading Jason Nemer – Inside the Magic of AcroYoga
Tim visited the Googleplex — the Mountain View-based headquarters of Google — and had a public chat. I was interviewed and made sure that we covered some ground that has not been discussed before. There were questions such as:
What has been the most important Stoic teaching that I’ve come across?
How do I manage the many requests I receive?
What are the factors or elements that have led to the success of the podcast?
Where do I see myself in five years?
If I could pick three people — alive or dead — to be in my personal board of directors, who would they be?
How do I experiment with my dog training?
What are my recommendations for longevity?
How do I fight insomnia?
Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health. If you enjoyed my last episode with Dr. Satchin Panda, I have good news! This will also be a great episode for you, since we talk about some similar ideas, but focus more on the human side of things, especially when it comes to time-restricted eating, since Dr. Patterson does primarily clinical research. In this 45-minute podcast, we talk about… The importance of time-restricted eating as a practical public health intervention, mostly for it’s ease of implementation, that may have a widespread impact on disease risk. Why you should probably make sure your time-restricted eating window occurs earlier in the day, rather than later. How the first 5% drop in weight loss can have disproportionately large effects on the metabolic factors associated with breast cancer risk when compared with subsequent weight loss. The association of longer fasting durations beginning earlier in the evening and improved sleep in humans, as well as spontaneous physical activity in their day-to-day lives. The relationship between metabolism and breast cancer risk. The effect of lifestyle factors, such as obesity, physical activity, what and even when you eat, whether or not you smoke tobacco… and how even modest changes, such as consuming food earlier in the day and only during an 11-hour window, can decrease breast cancer risk and recurrence by as much as 36%. The importance of starting your fast earlier in the evening, and how an earlier eating window has been shown to correlate to reductions in inflammatory markers.
Dr. Dominic “Dom” D’Agostino (@DominicDAgosti2) is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast.
Dom focuses on ketosis, ketones, and the ketogenic diet — so you can consider this a ketosis master class (especially if you combine both episodes, though this one does stand alone).
If you have an interest in these types of metabolic therapies, whether for performance enhancement, endurance, weight loss, or fighting cancer, diabetes, or any number of other maladies, you will find a gem within this episode.
Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin’s work deals specifically with the timing of food and it’s relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. In this video we discuss… The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. The relationship between our body’s “master clock” and it’s many peripheral clocks. Why infants sleep so intermittently, instead of resting for a longer, sustained duration like healthy young adults… and why this sustained rest also goes haywire in the elderly. The fascinating work Dr. Panda took part in that lead to the discovery of a specialized light receptor in the eye that sets circadian rhythms and is known as melanopsin. The important relationship between the relatively light insensitive melanopsin, which requires around 1,000 lux of light to be fully activated, and its control of the circadian clock by means of activation of the suprachiasmatic nucleus and suppression of melatonin. The effects light exposure seems to have on next-day cortisol, a glucocorticoid hormone that regulates around 10-20% of the human protein-encoding genome. The clever experimental design by which Dr. Panda and his colleagues discovered that certain circadian rhythms, especially of the liver, are entrained by when we eat, instead of how much light we get. This underlines the fact that, when managing are circadian rhythm, both elements are important! One of the more surprising effects of time-restricted feeding in mice eating a so-called healthy diet: increases in muscle mass and even endurance in some cases. Interested in trying out time-restricted feeding? Don’t let your data points go to waste! You can try out time-restricted feeding and have a real impact on human research! Commit to 14 weeks and download Dr. Panda’s mobile app to get started. Learn more at: mycircadianclock.org/participant