The power of the Ketogenic Diet with Dr. Dom D’Agostino

Dr. Dominic “Dom” D’Agostino (@DominicDAgosti2) is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast.

Dom focuses on ketosis, ketones, and the ketogenic diet — so you can consider this a ketosis master class (especially if you combine both episodes, though this one does stand alone).

If you have an interest in these types of metabolic therapies, whether for performance enhancement, endurance, weight loss, or fighting cancer, diabetes, or any number of other maladies, you will find a gem within this episode.

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Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health

Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin’s work deals specifically with the timing of food and it’s relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. In this video we discuss… The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. The relationship between our body’s “master clock” and it’s many peripheral clocks. Why infants sleep so intermittently, instead of resting for a longer, sustained duration like healthy young adults… and why this sustained rest also goes haywire in the elderly. The fascinating work Dr. Panda took part in that lead to the discovery of a specialized light receptor in the eye that sets circadian rhythms and is known as melanopsin. The important relationship between the relatively light insensitive melanopsin, which requires around 1,000 lux of light to be fully activated, and its control of the circadian clock by means of activation of the suprachiasmatic nucleus and suppression of melatonin. The effects light exposure seems to have on next-day cortisol, a glucocorticoid hormone that regulates around 10-20% of the human protein-encoding genome. The clever experimental design by which Dr. Panda and his colleagues discovered that certain circadian rhythms, especially of the liver, are entrained by when we eat, instead of how much light we get. This underlines the fact that, when managing are circadian rhythm, both elements are important! One of the more surprising effects of time-restricted feeding in mice eating a so-called healthy diet: increases in muscle mass and even endurance in some cases. Interested in trying out time-restricted feeding? Don’t let your data points go to waste! You can try out time-restricted feeding and have a real impact on human research! Commit to 14 weeks and download Dr. Panda’s mobile app to get started. Learn more at: mycircadianclock.org/participant

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Useful Lessons from Workaholics Anonymous, Corporate Implosions, and More

Ryan Holiday (@RyanHoliday) is a strategist and writer. He dropped out of college at 19 to apprentice under Robert Greene, author of The 48 Laws of Power, and later served as the director of marketing for American Apparel. His company, Brass Check, has advised clients like Google, TASER, and Complex, as well as many prominent bestselling authors. Holiday has written four previous books, including The Obstacle Is the Way, which has been translated into 17 languages and has a cult following among NFL coaches, world-class athletes, TV personalities, political leaders, and others around the world. Ryan lives on a small ranch outside of Austin, Texas, and his latest book is Ego Is The Enemy.

Ryan and Tim cover a lot in this conversation, including:

Meltdowns and how Ryan handles them
Workaholics Anonymous — How it works, what worked for him, what didn’t
The tipping points for his last book, The Obstacle Is the Way
External versus internal obstacles
Sherman versus Grant leadership and “success”
Howard Hughes versus Elon Musk
Thinking of “first principles”
If you only have 5 minutes, listen to what Ryan believes is one of the biggest threats to your creativity.

Enjoy!

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Tim Ferriss: Kevin Kelly – AI, Virtual Reality, and The Inevitable

Kevin is Senior Maverick at Wired Magazine, which he co-founded in 1993. He also co-founded the All Species Foundation, a non-profit aimed at cataloging and identifying every living species on earth. In his spare time, he writes bestselling books, co-founded The Rosetta Project, which is building an archive of all documented human languages, and serves on the board of The Long Now Foundation. As part of the last, he’s investigating how to revive and restore endangered or extinct species, including the Wooly Mammoth.

Kevin’s most recent project is The Inevitable: Understanding the 12 Technological Forces That Will Shape Our Future. The praise for the book is incredible, with Marc Andreessen saying it’s, “an automatic must-read.”

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Marc Andreessen — Lessons, Predictions, and Recommendations from an Icon

Marc Andreessen (@pmarca) is a legendary figure in Silicon Valley — and worldwide. Even in the epicenter of tech, it’s hard to find a more fascinating icon.

Marc co-created the highly influential Mosaic Internet browser, the first widely used graphical web browser. He also co-founded Netscape, which later sold to AOL for $4.2 billion. Then he co-founded Loudcloud, which sold as Opsware to Hewlett Packard for $1.6 billion.

He’s considered one of the founding fathers of the modern Internet, right alongside pioneers like Tim Berners-Lee, who launched the Uniform Resource Locator (URL), Hypertext Transfer Protocol (HTTP), and early HTML standards.

This all makes him one of the few humans ever to create software categories used by more than a billion people. He’s also one of the few who’s established multiple billion-dollar companies.

Marc is now co-founder and general partner of venture capital firm Andreessen Horowitz, where he’s quickly become one of the most influential and dominant tech investors in the world.

In this interview, Tim digs into some fun things Marc has not discussed in many places, including:

His epic debate vs. Peter Thiel
Rules for investing
The future of bitcoin
Artificial intelligence
Favorite books, documentaries, and movies
And much, much more
If you only have 5 minutes, here’s what Marc misses most about the mid-90s Internet (and what he’d like to bring back).

Please do say hi to Marc — he’s very active on Twitter at @pmarca.

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Found My Fitness Podcast: Ray Cronise, Cold Thermogenesis, Intermittent Fast, Weight Loss and Healthspan

Dr. Rhonda Patrick speaks with Ray Cronise, a former NASA material scientist and cofounder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers. In this episode, coming at the tail end of a rather extreme 23-day water fast for Ray, we discuss, perhaps unsurprisingly, some of the benefits that are associated with fasting! Ray talks about shifting one’s perspective from looking at nutrition only through the lens of meeting day-to-day nutritional needs, and instead, also considering optimizing metabolism for longer-term effects as well, the importance of thinking about longevity in the context of functional healthspan, some of the similarities between the body’s physiological response to heat stress, cold stress, and exercise and so much more. Learn more about Ray Cronise by visiting his website at hypothermics.com (raycronise.com) or by saying hello on twitter: twitter.com/raycronise. Finally, Ray also has a book available for pre-order called “Our Broken Plate.”

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How Seth Godin Manages His Life — Rules, Principles, and Obsessions (Tim Ferriss Show)

Seth Godin (@thisissethsblog) is the author of 17 bestselling books that have been translated into more than 35 languages. He writes about the way ideas spread, marketing, strategic quitting, leadership, and — most of all — challenging the status quo in all areas. His books include Linchpin, Tribes, The Dip, Purple Cow, and What to Do When it’s Your Turn (and it’s Always Your Turn).

Seth has founded several companies, including Yoyodyne and Squidoo. His blog (which you can find by typing “Seth” into Google) is one of the most popular in the world. In 2013, Godin was inducted into the Direct Marketing Hall of Fame. Recently, Godin turned the book publishing world on its ear by launching a series of four books via Kickstarter. The campaign reached its goal in just three hours and became the most successful book project in Kickstarter history.

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Joe Rogan Experience #773 – Dr. Rhonda Patrick

Dr. Rhonda Patrick returns with another nutrient dense discussion with Joe on cryotherapy/cold showers, diet, and exercise. As always this is not to be missed and we’ve noted all the most important parts for you, as it can be overwhelming in detail.

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The Tim Ferriss Show: Chris Sacca on Being Different and Making Billions

“Fuck it… I’m just not going to play this traditionally anymore.”
– Chris Sacca

Chris Sacca was recently the cover story of the “Midas Issue” of Forbes Magazine.

The reason: He is a newly-minted billionaire and the proprietor of what will likely be the most successful venture capital fund in history: LOWERCASE I of LOWERCASE Capital.

He’s an early-stage investor in companies like Twitter, Uber, Instagram, Kickstarter, and many more.

In this interview, we discuss unfair advantages, how Chris chooses founders and investments, stories of missed opportunities, the styles that differentiate Wall Street from Silicon Valley investors, and how keg parties can liberate law students from the tyranny of class (Chris completed law school without attending any classes).

Enjoy!

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The Tim Ferris Show: Chris Sacca on Shark Tank, Building Your Business, and Startup Mistakes

Sometimes one interview just isn’t enough. That was certainly the case with Tim’s good friend, Chris Sacca. Chris (who he interviewed before) was recently the cover story of the Midas Issue of Forbes magazine. He was on the cover because he’s a newly minted billionaire and the proprietor of what will likely be the most successful venture capital fund in history: LOWERCASE Capital.

He’s an early-stage investor in companies like Twitter, Uber, Instagram, Kickstarter, and many more.

Also, he wears cowboy shirts, has a great beard, and is hilarious, which is reason enough to bring him back for more. In this episode, he answers all of your most pressing questions based on your votes and feedback. You’ll find some fantastic responses, ranging from life advice to business recommendations and everything in between.

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