The power of the Ketogenic Diet with Dr. Dom D’Agostino

Dr. Dominic “Dom” D’Agostino (@DominicDAgosti2) is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast.

Dom focuses on ketosis, ketones, and the ketogenic diet — so you can consider this a ketosis master class (especially if you combine both episodes, though this one does stand alone).

If you have an interest in these types of metabolic therapies, whether for performance enhancement, endurance, weight loss, or fighting cancer, diabetes, or any number of other maladies, you will find a gem within this episode.

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Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health

Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin’s work deals specifically with the timing of food and it’s relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. In this video we discuss… The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. The relationship between our body’s “master clock” and it’s many peripheral clocks. Why infants sleep so intermittently, instead of resting for a longer, sustained duration like healthy young adults… and why this sustained rest also goes haywire in the elderly. The fascinating work Dr. Panda took part in that lead to the discovery of a specialized light receptor in the eye that sets circadian rhythms and is known as melanopsin. The important relationship between the relatively light insensitive melanopsin, which requires around 1,000 lux of light to be fully activated, and its control of the circadian clock by means of activation of the suprachiasmatic nucleus and suppression of melatonin. The effects light exposure seems to have on next-day cortisol, a glucocorticoid hormone that regulates around 10-20% of the human protein-encoding genome. The clever experimental design by which Dr. Panda and his colleagues discovered that certain circadian rhythms, especially of the liver, are entrained by when we eat, instead of how much light we get. This underlines the fact that, when managing are circadian rhythm, both elements are important! One of the more surprising effects of time-restricted feeding in mice eating a so-called healthy diet: increases in muscle mass and even endurance in some cases. Interested in trying out time-restricted feeding? Don’t let your data points go to waste! You can try out time-restricted feeding and have a real impact on human research! Commit to 14 weeks and download Dr. Panda’s mobile app to get started. Learn more at: mycircadianclock.org/participant

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Useful Lessons from Workaholics Anonymous, Corporate Implosions, and More

Ryan Holiday (@RyanHoliday) is a strategist and writer. He dropped out of college at 19 to apprentice under Robert Greene, author of The 48 Laws of Power, and later served as the director of marketing for American Apparel. His company, Brass Check, has advised clients like Google, TASER, and Complex, as well as many prominent bestselling authors. Holiday has written four previous books, including The Obstacle Is the Way, which has been translated into 17 languages and has a cult following among NFL coaches, world-class athletes, TV personalities, political leaders, and others around the world. Ryan lives on a small ranch outside of Austin, Texas, and his latest book is Ego Is The Enemy.

Ryan and Tim cover a lot in this conversation, including:

Meltdowns and how Ryan handles them
Workaholics Anonymous — How it works, what worked for him, what didn’t
The tipping points for his last book, The Obstacle Is the Way
External versus internal obstacles
Sherman versus Grant leadership and “success”
Howard Hughes versus Elon Musk
Thinking of “first principles”
If you only have 5 minutes, listen to what Ryan believes is one of the biggest threats to your creativity.

Enjoy!

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Found My Fitness Podcast: Ray Cronise, Cold Thermogenesis, Intermittent Fast, Weight Loss and Healthspan

Dr. Rhonda Patrick speaks with Ray Cronise, a former NASA material scientist and cofounder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers. In this episode, coming at the tail end of a rather extreme 23-day water fast for Ray, we discuss, perhaps unsurprisingly, some of the benefits that are associated with fasting! Ray talks about shifting one’s perspective from looking at nutrition only through the lens of meeting day-to-day nutritional needs, and instead, also considering optimizing metabolism for longer-term effects as well, the importance of thinking about longevity in the context of functional healthspan, some of the similarities between the body’s physiological response to heat stress, cold stress, and exercise and so much more. Learn more about Ray Cronise by visiting his website at hypothermics.com (raycronise.com) or by saying hello on twitter: twitter.com/raycronise. Finally, Ray also has a book available for pre-order called “Our Broken Plate.”

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Joe Rogan Experience #773 – Dr. Rhonda Patrick

Dr. Rhonda Patrick returns with another nutrient dense discussion with Joe on cryotherapy/cold showers, diet, and exercise. As always this is not to be missed and we’ve noted all the most important parts for you, as it can be overwhelming in detail.

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Rich Roll Podcast: Dr. Rhonda Patrick

LONGEVITY, EPIGENETICS, MICROBIOME HEALTH & THE DIFFERENCE BETWEEN EATING FOR LONG-TERM WELLNESS VERSUS PERFORMANCE

This episode is a geeky deep dive into the hardcore science behind everything from telomeres and the mechanisms behind aging and longevity to the primacy of maintaining microbiome health; oxidative stress and the relationship between inflammation and chronic disease; epigenetics and genetic disposition versus expression; and of course nutrition – divining truth from myth, the impact of micronutrient inadequacies, focused supplementation and the difference between eating for optimal wellness versus performance.

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The Tim Ferriss Show: Derek Sivers Reloaded – On Success Habits and Billionaires with Perfect Abs

By popular demand, this is a follow-up with the amazing Derek Sivers (@sivers)!

This episode can be listened to independently of Tim’s first popular conversation, and he answers some of my (and your) favorite questions.

Originally a professional musician and circus clown, Derek created CD Baby in 1998. It became the largest seller of independent music online, with $100 million in sales for 150,000 musicians.

If you only listen to one answer from this episode, don’t miss his response to “What do you believe that other people think is insane?” It get progressively weirder and weirder and starts around 34:09

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Found My Fitness Podcast: Dr. Pierre Capel on the Power of the Mind & the Science of Wim Hof

Rhonda speaks with Dr. Pierre Capel, professor of experimental immunology who has studied Wim Hof to bring the science to explain his incredible ability to withstand cold and summon his immune system at well. Through this insightful discussion they also cover how the immune system is impacted by stress/meditation and just how dynamic our DNA really is.

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