Dom D’Agostino on Disease Prevention, Cancer, and Living Longer

An amazing Q&A with the one and only Dom D’Agostino.

Dom is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC) — which is mentioned in the current issue of Outside Magazine (on which there’s a clown who looks a lot like me).

Much of Dom’s work is related to metabolic therapies and nutritional strategies for peak performance and resilience in extreme environments. Dom’s research is supported by the Office of Naval Research (ONR), Department of Defense (DoD), and other private organizations and foundations.

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Tim Ferriss Show: Jocko Willink on Discipline, Leadership, and Overcoming Doubt

Jocko Willink (@jockowillink) is one of the scariest human beings imaginable. Jocko did his first interview with tim and it took the Internet by storm. Now he is back for round two to answer the questions you’ve been asking.

Jocko is a lean 230 pounds. He is a Brazilian jiu-jitsu expert who used to tap out 20 Navy SEALs per workout. He is a legend in the Special Operations world. His eyes look through you more than at you.

Jocko spent 20 years in the US Navy and commanded SEAL Team 3’s task unit Bruiser, the most highly decorated special operations unit in the Iraq War. Upon returning to the US, Jocko served as the officer in charge of training for all West Coast SEAL teams, designing and implementing some of the most challenging and realistic — and perhaps psychotic — combat training in the world (his words, not mine).

After retiring from the Navy, he co-founded Echelon Front, a leadership and management consulting company and authored the number one New York Times bestseller Extreme Ownership: How US Navy SEALs Lead and Win.

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Radiolab: From Tree to Shining Tree

A forest can feel like a place of great stillness and quiet. But if you dig a little deeper, there’s a hidden world beneath your feet as busy and complicated as a city at rush hour.

In this story, a dog introduces us to a strange creature that burrows beneath forests, building an underground network where deals are made and lives are saved (and lost) in a complex web of friendships, rivalries, and business relations. It’s a network that scientists are only just beginning to untangle and map, and it’s not only turning our understanding of forests upside down, it’s leading some researchers to rethink what it means to be intelligent.

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Jason Nemer – Inside the Magic of AcroYoga

LISTEN The guest on this episode of the podcast is Jason Nemer, co-founder of AcroYoga. What are the origins of AcroYoga? Jason had some sport acrobat experience, a mix between gymnastics and figure skating. Jenny had experience in therapeutic flying. AcroYoga is the combination of those two practices. It helps with flexibility and mobility. What … Continue reading Jason Nemer – Inside the Magic of AcroYoga

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Seth Godin on How to Think Small to Go Big

Seth Godin (@thisissethsblog) is the author of 17 bestselling books that have been translated into more than 35 languages. He writes about the way ideas spread, marketing, strategic quitting, leadership, and — most of all — challenging the status quo in all areas. His books include Linchpin, Tribes, The Dip, Purple Cow, and What to Do When it’s Your Turn (and it’s Always Your Turn).

Seth has founded several companies, including Yoyodyne and Squidoo. His blog (which you can find by typing “Seth” into Google) is one of the most popular in the world. In 2013, Godin was inducted into the Direct Marketing Hall of Fame. Recently, Godin turned the book publishing world on its ear by launching a series of four books via Kickstarter. The campaign reached its goal in just three hours and became the most successful book project in Kickstarter history.

You’ll find pithy, actionable things that you can implement, such has how to keep track of the right things and how to create a narrative that serves you best. It’s very simple, but it’s a foundational skill and mindset.

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Tim Ferriss: How to Cage the Monkey Mind

Tim visited the Googleplex — the Mountain View-based headquarters of Google — and had a public chat. I was interviewed and made sure that we covered some ground that has not been discussed before. There were questions such as:

What has been the most important Stoic teaching that I’ve come across?
How do I manage the many requests I receive?
What are the factors or elements that have led to the success of the podcast?
Where do I see myself in five years?
If I could pick three people — alive or dead — to be in my personal board of directors, who would they be?
How do I experiment with my dog training?
What are my recommendations for longevity?
How do I fight insomnia?

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Time-Restricted Eating in Humans & Breast Cancer Prevention‬

Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health. If you enjoyed my last episode with Dr. Satchin Panda, I have good news! This will also be a great episode for you, since we talk about some similar ideas, but focus more on the human side of things, especially when it comes to time-restricted eating, since Dr. Patterson does primarily clinical research. In this 45-minute podcast, we talk about… The importance of time-restricted eating as a practical public health intervention, mostly for it’s ease of implementation, that may have a widespread impact on disease risk. Why you should probably make sure your time-restricted eating window occurs earlier in the day, rather than later. How the first 5% drop in weight loss can have disproportionately large effects on the metabolic factors associated with breast cancer risk when compared with subsequent weight loss. The association of longer fasting durations beginning earlier in the evening and improved sleep in humans, as well as spontaneous physical activity in their day-to-day lives. The relationship between metabolism and breast cancer risk. The effect of lifestyle factors, such as obesity, physical activity, what and even when you eat, whether or not you smoke tobacco… and how even modest changes, such as consuming food earlier in the day and only during an 11-hour window, can decrease breast cancer risk and recurrence by as much as 36%. The importance of starting your fast earlier in the evening, and how an earlier eating window has been shown to correlate to reductions in inflammatory markers.

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The power of the Ketogenic Diet with Dr. Dom D’Agostino

Dr. Dominic “Dom” D’Agostino (@DominicDAgosti2) is an assistant professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine, and a senior research scientist at the Institute for Human and Machine Cognition (IHMC). He has also deadlifted 500 pounds for 10 reps after a seven-day fast.

Dom focuses on ketosis, ketones, and the ketogenic diet — so you can consider this a ketosis master class (especially if you combine both episodes, though this one does stand alone).

If you have an interest in these types of metabolic therapies, whether for performance enhancement, endurance, weight loss, or fighting cancer, diabetes, or any number of other maladies, you will find a gem within this episode.

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Time-Restricted Feeding and Its Effects on Obesity, Muscle Mass & Heart Health

Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin’s work deals specifically with the timing of food and it’s relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general. In this video we discuss… The fascinating history of experimentation that ultimately elucidated the location for the region of the brain necessary for a properly timed sleep-wake cycles. The relationship between our body’s “master clock” and it’s many peripheral clocks. Why infants sleep so intermittently, instead of resting for a longer, sustained duration like healthy young adults… and why this sustained rest also goes haywire in the elderly. The fascinating work Dr. Panda took part in that lead to the discovery of a specialized light receptor in the eye that sets circadian rhythms and is known as melanopsin. The important relationship between the relatively light insensitive melanopsin, which requires around 1,000 lux of light to be fully activated, and its control of the circadian clock by means of activation of the suprachiasmatic nucleus and suppression of melatonin. The effects light exposure seems to have on next-day cortisol, a glucocorticoid hormone that regulates around 10-20% of the human protein-encoding genome. The clever experimental design by which Dr. Panda and his colleagues discovered that certain circadian rhythms, especially of the liver, are entrained by when we eat, instead of how much light we get. This underlines the fact that, when managing are circadian rhythm, both elements are important! One of the more surprising effects of time-restricted feeding in mice eating a so-called healthy diet: increases in muscle mass and even endurance in some cases. Interested in trying out time-restricted feeding? Don’t let your data points go to waste! You can try out time-restricted feeding and have a real impact on human research! Commit to 14 weeks and download Dr. Panda’s mobile app to get started. Learn more at: mycircadianclock.org/participant

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